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AffiliationDivision of Therapeutics and Molecular MedicineQueen’s Medical CentreNottinghamUnited Kingdom.
This subsection of the Family and Domains section describes the position and type of a domainwhich is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.
Abnormal alpha-1 antitrypsin proteins may bind together to form a large moleculeor polymerthat cannot leave the liverThe accumulation of these polymers results in liver damageIn additionlung tissue is destroyed because not enough alpha-1 antitrypsin is available to protect against neutrophil elastasePolymers of alpha-1 antitrypsin may also contribute to excessive inflammationwhich may explain some of the other features of alpha-1 antitrypsin deficiencysuch as a skin condition called panniculitis.
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anti-serpina1 alpha 1 antitrypsin rabbit monoclonal antibody.
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