Some people using sinemet sr have had car accidents because they fell asleep while driving.
Information about Sinemet.
SINEMET is contraindicated in patients with known hypersensitivity to any component of this drugand in patients with narrow-angle glaucoma.
Other adverse reactions that have been reported with levodopa alone and with various carbidopa levodopa formulationsand may occur with SINEMET are:
Carbidopa works by preventing the breakdown of levodopa by decarboxylase enzymesBecause it cannot cross the blood-brain barriercarbidopa ensures the safe delivery of levodopa to the brainwhere it becomes exposed to the action of the decarboxylases that generate dopamine.
SINEMET helps control some of your symptoms of Parkinson’s diseasebut does not cure itTherefore SINEMET must be taken every dayContinue taking SINEMET for as long as your doctor prescribes.
When levodopa is administered orallyit is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous systemFor this reasonlarge doses of levodopa are required for adequate therapeutic effectand these may often be accompanied by nausea and other adverse reactionssome of which are attributable to dopamine formed in extracerebral tissues.
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because the bioavailabilities of carbidopa and levodopa in sinemet and sinemet cr are different, appropriate adjustments should be made, as shown in table 2.
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