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Serious cardiac eventsincluding some that have been fatalhave occurred following use of 5-HT 1 agonistsThese events are extremely rare and most have been reported in patients with risk factors predictive of CADEvents reported have included coronary artery vasospasmtransient myocardial ischaemiamyocardial infarctionventricular tachycardia and ventricular fibrillation.
Following oral administration of 14 C-labelled rizatriptanrizatriptan accounts for about 17of circulating plasma radioactivity.
Rizatriptan should be used with caution in dialysis patients due to a decrease in the clearance of rizatriptan.
Factors that trigger this headache type are a muscle strainstress or anxiety.
Cerebral haemorrhagesubarachnoid haemorrhagestroke and other cerebrovascular events have been reported in patients treated with 5-HT 1 agonistsand some have resulted in fatalitiesIn a number of casesit appears possible that the cerebrovascular events were primarythe agonist having been administered in the incorrect belief that the symptoms experienced were a consequence of migrainewhen they were notIt should be noted that patients with migraine may be at increased risk of certain cerebrovascular eventse.gstrokehaemorrhagetransient ischaemic attack
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